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Pre-mRNA Processing Factor 6 (PRPF6)

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C20orf14; TOM; ANT-1; Prp6; U5 snRNP-associated 102 kDa protein; Androgen receptor N-terminal domain-transactivating protein 1

Pre-mRNA Processing Factor 6 (PRPF6)
CCC Q480
HGNC 15860
MGI 1922946
PubMed 21549338
RGD 1307103
UniProt O94906
Wiki PRPF6
PRP6 appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. Predicted amino acid sequence of the protein is similar to those of yeast splicing factors, Prp1p/Zer1p of Schizosaccharomyces pombe and Prp6p of Saccharomyces cerevisiae. Among these proteins, tetratrico peptide repeat (TPR) motif, which mediates protein-protein interactions, is conserved, whereas leucine zipper motif is found only in the 100-kDa protein. Indirect immunofluorescent staining showed that the 100-kDa protein localized in the nucleus in HeLa cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-mRNA Processing Factor 6 (PRPF6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-mRNA Processing Factor 6 (PRPF6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-mRNA Processing Factor 6 (PRPF6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-mRNA Processing Factor 6 (PRPF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-mRNA Processing Factor 6 (PRPF6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-mRNA Processing Factor 6 (PRPF6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-mRNA Processing Factor 6 (PRPF6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-mRNA Processing Factor 6 (PRPF6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-mRNA Processing Factor 6 (PRPF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-mRNA Processing Factor 6 (PRPF6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-mRNA Processing Factor 6 (PRPF6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-mRNA Processing Factor 6 (PRPF6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-mRNA Processing Factor 6 (PRPF6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-mRNA Processing Factor 6 (PRPF6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-mRNA Processing Factor 6 (PRPF6) ELISA Kit Customized Service Offer
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  2. "The human homologue of the yeast splicing factor Prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions."J. Mol. Biol. 298:567-575(2000) [PubMed] [Europe PMC] [Abstract]
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  8. "Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor."J. Biol. Chem. 277:30031-30039(2002) [PubMed] [Europe PMC] [Abstract]
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  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "A missense mutation in PRPF6 causes impairment of pre-mRNA splicing and autosomal-dominant retinitis pigmentosa."Am. J. Hum. Genet. 88:643-649(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Mutations in the gene DNAJC5 cause autosomal dominant Kufs disease in a proportion of cases: study of the Parry family and 8 other families."PLoS ONE 7:E29729-E29729(2012) [PubMed] [Europe PMC] [Abstract]