Sfxn3, a member of sideroflexin family. CTPL/Sfxn3 was targeted to mitochondrial membrane like Sfxn1. The expression levels of CTPL/Sfxn3, Sfxn2, and Sfxn5 were upregulated in the early phase of differentiation into insulin-secreting cells but the expression levels of Sfxn1 and Sfxn3 did not change. All Sfxn family members were expressed in rat pancreatic islet. The expression levels of CTPL/Sfxn3, Sfxn2, and Sfxn5 were also upregulated in islets of streptozotocin-induced diabetic rats compared to normal rats. The downregulation of CTPL/Sfxn3 in a rat insulinoma cell line, INS-1, with the antisense oligonucleotide did not affect the insulin secretion. Taken together, CTPL/Sfxn3 and some other family members might be important in the differentiation of pancreatic beta-cells as a channel or a carrier molecule and be related to the regeneration of pancreatic endocrine cells.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPQ501Hu01 | Recombinant Sideroflexin 3 (SFXN3) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to Sideroflexin 3 (SFXN3) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Sideroflexin 3 (SFXN3) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Sideroflexin 3 (SFXN3) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Sideroflexin 3 (SFXN3) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Sideroflexin 3 (SFXN3) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Sideroflexin 3 (SFXN3) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Sideroflexin 3 (SFXN3) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Sideroflexin 3 (SFXN3) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Sideroflexin 3 (SFXN3) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Sideroflexin 3 (SFXN3) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Sideroflexin 3 (SFXN3) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Sideroflexin 3 (SFXN3) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Sideroflexin 3 (SFXN3) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Sideroflexin 3 (SFXN3) | ELISA Kit Customized Service Offer |
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]