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Defensin Beta 127 (DEFb127)

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DEF-27; C20orf73

Defensin Beta 127 (DEFb127)
CCC Q512
HGNC 16206
PubMed 11854508
UniProt Q9H1M4
Wiki DEFB127
Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. DEFb127 is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13.
DEFB127 gives a significantly negative value for the MB and a significantly positive value for the UK population, which may indicate balancing selection. For DEFB127, D, H, and Fu's Fs are all significantly negative for the MB population, which suggests directional selection in this population. For DEFB127, Tajima's D is significantly positive in the UK population reflection a signal of either balancing selection or population subdivision.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Defensin Beta 127 (DEFb127) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Defensin Beta 127 (DEFb127) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Defensin Beta 127 (DEFb127) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Defensin Beta 127 (DEFb127) CLIA Kit Customized Service Offer
n/a ELISA Kit for Defensin Beta 127 (DEFb127) ELISA Kit Customized Service Offer
  1. "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis."Genomics 81:175-183(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Discovery of five conserved beta-defensin gene clusters using a computational search strategy."Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]