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Tripartite Motif Containing Protein 4 (TRIM4)

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RNF87; RING finger protein 87; E3 ubiquitin-protein ligase TRIM4

Tripartite Motif Containing Protein 4 (TRIM4)
CCC Q521
HGNC 16275
PubMed 10916143
UniProt Q9C037
TRIM4 is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternatively spliced transcript variants that encode different isoforms have been described. A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tripartite motif (TRIM).
A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo-multimerization they identify specific cell compartments.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tripartite Motif Containing Protein 4 (TRIM4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tripartite Motif Containing Protein 4 (TRIM4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tripartite Motif Containing Protein 4 (TRIM4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tripartite Motif Containing Protein 4 (TRIM4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tripartite Motif Containing Protein 4 (TRIM4) ELISA Kit Customized Service Offer
  1. "The tripartite motif family identifies cell compartments."EMBO J. 20:2140-2151(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "TRIM4 modulates type I interferon induction and cellular antiviral response by targeting RIG-I for K63-linked ubiquitination."J. Mol. Cell Biol. 6:154-163(2014) [PubMed] [Europe PMC] [Abstract]