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WW Domain Binding Protein 11 (WBP11)

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NPWBP; SIPP1; SNP70; Splicing Factor, PQBP1 And PP1 Interacting; Npw38-binding protein; SH3 domain-binding protein SNP70

WW Domain Binding Protein 11 (WBP11)
CCC Q535
HGNC 16461
MGI 1891823
PubMed 10593949
RGD 1307911
UniProt Q9Y2W2
Wiki WBP11
WBP11 colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus. Npw38 and NpwBP are colocalized in the same subnuclear region. Coimmunoprecipitation experiments confirmed the association between Npw38 and NpwBP, which were expressed as epitope-tagged forms in COS7 cells. NpwBP is a physiological ligand of Npw38 and that the Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WW Domain Binding Protein 11 (WBP11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WW Domain Binding Protein 11 (WBP11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WW Domain Binding Protein 11 (WBP11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WW Domain Binding Protein 11 (WBP11) CLIA Kit Customized Service Offer
n/a ELISA Kit for WW Domain Binding Protein 11 (WBP11) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WW Domain Binding Protein 11 (WBP11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WW Domain Binding Protein 11 (WBP11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WW Domain Binding Protein 11 (WBP11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WW Domain Binding Protein 11 (WBP11) CLIA Kit Customized Service Offer
n/a ELISA Kit for WW Domain Binding Protein 11 (WBP11) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WW Domain Binding Protein 11 (WBP11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WW Domain Binding Protein 11 (WBP11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WW Domain Binding Protein 11 (WBP11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WW Domain Binding Protein 11 (WBP11) CLIA Kit Customized Service Offer
n/a ELISA Kit for WW Domain Binding Protein 11 (WBP11) ELISA Kit Customized Service Offer
  1. "Association of two nuclear proteins, Npw38 and NpwBP, via the interaction between the WW domain and a novel proline-rich motif containing glycine and arginine."J. Biol. Chem. 274:36513-36519(1999) [PubMed] [Europe PMC] [Abstract]
  2. "A nuclear SH3 domain-binding protein that colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks."J. Biol. Chem. 276:30552-30560(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1."Biochem. J. 378:229-238(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21)."J. Biol. Chem. 284:25375-25387(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Y65C missense mutation in the WW domain of the Golabi-Ito-Hall syndrome protein PQBP1 affects its binding activity and deregulates pre-mRNA splicing."J. Biol. Chem. 285:19391-19401(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]