≡

Small Acidic Protein (SMAP)

[Edit]

C11orf58

Small Acidic Protein (SMAP)
CCC Q576
HGNC 16990
MGI 1929274
PubMed 16923017
RGD 1311703
UniProt O00193
Wiki C11orf58
SMAP1 and SMAP2 proteins constitute a subfamily of the Arf-specific GTPase-activating proteins. SMAP proteins bind to clathrin heavy chains and are involved in the trafficking of clathrin-coated vesicles. In cells, SMAP1 regulates Arf6-dependent endocytosis of transferrin receptors from the coated pits of the plasma membrane, whereas SMAP2 regulates Arf1-dependent retrograde transport of TGN38 from the early endosome to the trans-Golgi network. The common and distinct features of SMAP1 and SMAP2 activity provide a valuable opportunity to examine the differential regulation of membrane trafficking by these two proteins. In addition, a yeast two-hybrid system is described because of its utility in identifying novel molecules that interact with SMAP.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Acidic Protein (SMAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Acidic Protein (SMAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Acidic Protein (SMAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Acidic Protein (SMAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Acidic Protein (SMAP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Acidic Protein (SMAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Acidic Protein (SMAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Acidic Protein (SMAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Acidic Protein (SMAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Acidic Protein (SMAP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Small Acidic Protein (SMAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Small Acidic Protein (SMAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Small Acidic Protein (SMAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Small Acidic Protein (SMAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for Small Acidic Protein (SMAP) ELISA Kit Customized Service Offer
  1. "Novel genes expressed in the chick otocyst during development: identification using differential display of RNA."Int. J. Dev. Neurosci. 15:585-594(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]