≡

Cytoskeleton Associated Protein 4 (CKAP4)

[Edit]

P63; CLIMP-63; ERGIC-63; 63-kDa cytoskeleton-linking membrane protein

Cytoskeleton Associated Protein 4 (CKAP4)
CCC Q577
HGNC 16991
MGI 2444926
PubMed 21143984
RGD 1311989
UniProt Q07065
Wiki CKAP4
p63, is a resident protein of a membrane network interposed in between rough ER and Golgi apparatus. To characterize p63 at the molecular level a 2.91 kb cDNA encoding p63 has been isolated from a human placenta lambda gt10 cDNA library. Sequence analysis of tryptic peptides prepared from isolated p63 confirmed the identify of the cloned gene. The human p63 cDNA exhibits a high level of sequence identify to the pig hepatic cDNA 3AL whose expression is enhanced after resuscitation from circulatory shock. An additional remarkable feature of p63 is that it becomes reversibly palmitoylated when intracellular protein transport is blocked by the drug brefeldin A. Overexpression of p63 in COS cells led to the development of a striking tubular membrane network in the cytoplasm.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ577Hu01 Recombinant Cytoskeleton Associated Protein 4 (CKAP4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Cytoskeleton Associated Protein 4 (CKAP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytoskeleton Associated Protein 4 (CKAP4) Polyclonal Antibody Customized Service Offer
Assay Kits SEQ577Hu ELISA Kit for Cytoskeleton Associated Protein 4 (CKAP4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytoskeleton Associated Protein 4 (CKAP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytoskeleton Associated Protein 4 (CKAP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytoskeleton Associated Protein 4 (CKAP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytoskeleton Associated Protein 4 (CKAP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytoskeleton Associated Protein 4 (CKAP4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cytoskeleton Associated Protein 4 (CKAP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cytoskeleton Associated Protein 4 (CKAP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cytoskeleton Associated Protein 4 (CKAP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cytoskeleton Associated Protein 4 (CKAP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytoskeleton Associated Protein 4 (CKAP4) ELISA Kit Customized Service Offer
  1. "A reversibly palmitoylated resident protein(p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein."J. Cell Sci. 104:685-694(1993) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Phosphorylation controls CLIMP-63-mediated anchoring of the endoplasmic reticulum to microtubules."Mol. Biol. Cell 16:1928-1937(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "CKAP4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients."J. Biol. Chem. 281:37836-37843(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Climp-63-mediated binding of microtubules to the ER affects the lateral mobility of translocon complexes."J. Cell Sci. 120:2248-2258(2007) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling."Mol. Biol. Cell 20:1454-1463(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]