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RUN And SH3 Domain Containing Protein 1 (RUSC1)

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NESCA; New molecule containing SH3 at the carboxy-terminus

RUN And SH3 Domain Containing Protein 1 (RUSC1)
CCC Q589
HGNC 17153
MGI 1919546
PubMed 22404429
UniProt Q9BVN2
RUSC1 consisting of 11 exons, was mapped to human chromosome 1q22. RUSC2 gene, consisting of 12 exons was mapped to human chromosome 9p13. Human RUSC1 gene as well as mouse Rusc1 gene were found to encode two isoforms with or without 411-bp exon 3 due to alternative splicing of exon-skipping type. RUSC1 and RUSC2 showed 30.5% total amino-acid identity. Human RUSC1, RUSC2, mouse Rusc1 and Rusc2 proteins were found to share the common domain structure, consisting of RUN, Leucine zipper, and SH3 domains. RUSC1, RUSC2, RIPX, RUFY1, RUFY2, RUTBC1, RUTBC2, RUTBC3, RUB6IP1, and PLEKHM1 were RUN domain proteins within the human proteome. This is the first report on comprehensive characterization of RUSC1 and RUSC2 orthologs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RUN And SH3 Domain Containing Protein 1 (RUSC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RUN And SH3 Domain Containing Protein 1 (RUSC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RUN And SH3 Domain Containing Protein 1 (RUSC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RUN And SH3 Domain Containing Protein 1 (RUSC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RUN And SH3 Domain Containing Protein 1 (RUSC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RUN And SH3 Domain Containing Protein 1 (RUSC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RUN And SH3 Domain Containing Protein 1 (RUSC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RUN And SH3 Domain Containing Protein 1 (RUSC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RUN And SH3 Domain Containing Protein 1 (RUSC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for RUN And SH3 Domain Containing Protein 1 (RUSC1) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of a novel human gene (NESCA) which encodes a putative adapter protein containing SH3."Biochim. Biophys. Acta 1491:321-326(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Nesca, a novel adapter, translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth."J. Cell Biol. 164:851-862(2004) [PubMed] [Europe PMC] [Abstract]
  8. "NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein."J. Cell. Physiol. 220:410-417(2009) [PubMed] [Europe PMC] [Abstract]