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Zinc Finger CCCH-Type Containing Protein 12B (ZC3H12B)

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CXorf32; MCPIP2; MCP Induced Protein 2; Probable ribonuclease ZC3H12B

Zinc Finger CCCH-Type Containing Protein 12B (ZC3H12B)
CCC Q605
HGNC 17407
MGI 2442133
PubMed 18178554
UniProt Q5HYM0
Activated macrophages play an important role in many inflammatory diseases. However, the molecular mechanisms controlling macrophage activation are not completely understood. MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a, Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage activation. Northern blot analysis revealed that the expression of MCPIP1 and MCPIP3 was highly induced in macrophages in response to treatment with lipopolysaccharide (LPS).
ZC3H12B belongs to a family of CCCH-type zinc finger proteins that are involved in the proinflammatory activation of macrophages. The exact function of this family member is unknown, but it is thought to function as a ribonuclease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger CCCH-Type Containing Protein 12B (ZC3H12B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger CCCH-Type Containing Protein 12B (ZC3H12B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger CCCH-Type Containing Protein 12B (ZC3H12B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger CCCH-Type Containing Protein 12B (ZC3H12B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger CCCH-Type Containing Protein 12B (ZC3H12B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Zinc Finger CCCH-Type Containing Protein 12B (ZC3H12B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Zinc Finger CCCH-Type Containing Protein 12B (ZC3H12B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Zinc Finger CCCH-Type Containing Protein 12B (ZC3H12B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Zinc Finger CCCH-Type Containing Protein 12B (ZC3H12B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Zinc Finger CCCH-Type Containing Protein 12B (ZC3H12B) ELISA Kit Customized Service Offer
  1. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages."J. Biol. Chem. 283:6337-6346(2008) [PubMed] [Europe PMC] [Abstract]