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Ring Finger Protein 138 (RNF138)

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STRIN; NARF; HSD4; E3 ubiquitin-protein ligase RNF138; Nemo-like kinase-associated RING finger protein

Ring Finger Protein 138 (RNF138)
CCC Q618
HGNC 17765
MGI 1929211
PubMed 22155992
RGD 621485
UniProt Q8WVD3
RNF138 contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. RNF138 is an E3 ubiquitin-protein ligase and together with NLK, is involved in the ubiquitination and degradation of TCF/LEF. RNF138 may act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.
The present study demonstrates that the genes, RNF138, MT2A, and STEAP3 are differently expressed in the inflamed descending colon of smoking versus never-smoking CD patients, which might be of relevance for the poorer clinical course among CD smokers.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 138 (RNF138) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 138 (RNF138) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 138 (RNF138) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 138 (RNF138) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 138 (RNF138) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 138 (RNF138) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 138 (RNF138) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 138 (RNF138) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 138 (RNF138) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 138 (RNF138) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ring Finger Protein 138 (RNF138) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ring Finger Protein 138 (RNF138) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ring Finger Protein 138 (RNF138) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ring Finger Protein 138 (RNF138) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ring Finger Protein 138 (RNF138) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)."J. Biol. Chem. 281:20749-20760(2006) [PubMed] [Europe PMC] [Abstract]
  5. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]