TBC1 Domain Family, Member 8 (TBC1D8)
[Edit]HBLP1; VRP; AD3; BUB2-Like Protein 1; Vascular Rab-GAP/TBC-containing protein
An almost identical expression pattern was observed in cells treated with either Taxol or EpoB. Low concentrations of the drugs induced aberrant mitosis including asymmetric and multipolar cell divisions. At drug concentrations that triggered G(2)-M arrest, cells escaped from a prolonged mitotic arrest without cell division, resulting in tetraploid G(1) cells. This mitotic slippage is correlated with diminished expression of cdc2 kinase, topoisomerase IIalpha, BUB3, and BUB2-like protein 1, as well as with an increased expression of 14-3-3-sigma. Poly (ADP-ribose) polymerase cleavage, an early indicator of apoptosis, occurred in cells undergoing mitotic slippage and in aneuploid cells resulting from aberrant mitosis. In contrast, cells arrested in mitosis demonstrated no signal for apoptosis but had an increased expression of survivin, an inhibitor of apoptosis.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant TBC1 Domain Family, Member 8 (TBC1D8) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to TBC1 Domain Family, Member 8 (TBC1D8) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to TBC1 Domain Family, Member 8 (TBC1D8) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for TBC1 Domain Family, Member 8 (TBC1D8) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for TBC1 Domain Family, Member 8 (TBC1D8) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant TBC1 Domain Family, Member 8 (TBC1D8) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to TBC1 Domain Family, Member 8 (TBC1D8) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to TBC1 Domain Family, Member 8 (TBC1D8) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for TBC1 Domain Family, Member 8 (TBC1D8) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for TBC1 Domain Family, Member 8 (TBC1D8) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant TBC1 Domain Family, Member 8 (TBC1D8) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to TBC1 Domain Family, Member 8 (TBC1D8) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to TBC1 Domain Family, Member 8 (TBC1D8) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for TBC1 Domain Family, Member 8 (TBC1D8) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for TBC1 Domain Family, Member 8 (TBC1D8) | ELISA Kit Customized Service Offer |
- "Antisense display -- a method for functional gene screening: evaluation in a cell-free system and isolation of angiogenesis-related genes."Nucleic Acids Res. 27:2591-2600(1999) [PubMed] [Europe PMC] [Abstract]
- "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity."Genes Cells 14:41-52(2009) [PubMed] [Europe PMC] [Abstract]
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]