RAB40A, Member RAS Oncogene Family (RAB40A)

RAB40A encodes a member of the Rab40 subfamily of Rab small GTP-binding proteins that contains a C-terminal suppressors of cytokine signaling box.

The human RAB40A gene and the RAB40AL gene have a closer relation to each other than to their orthologs. In fact, it would seem that RAB40AL has donated part of its sequence to RAB40A, because the human RAB40A is located within the RAB40AL genes subtree. The detailed synteny graph of the region around these genes shown in the Supplementary Data indicates, that this is a highly conserved region where gene order has been well kept including a few other gene families such as the BEX and TCEAL genes.