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Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2)

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SBBI57; Serine/threonine-protein phosphatase 4 regulatory subunit 2

Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2)
CCC Q684
HGNC 18296
MGI 3027896
PubMed 10769191
RGD 1307312
UniProt Q9NY27
Protein phosphatase 4 (PPP4) is a protein serine/threonine phosphatase that has been implicated in microtubule organization at centrosomes.The encoded putative PPP4 regulatory subunit (termed PPP4R2), comprising 453 amino acids, had a molecular mass of 50.4 kDa. The interaction of PPP4R2 with PPP4 catalytic subunit (PPP4c) was confirmed by co-sedimentation of PPP4c with PPP4R2 expressed in bacteria and human cells. PPP4c formed a complex of 450 kDa with baculovirus expressed His(6)-tagged PPP4R2. Immunocytological detection of PPP4R2 at centrosomes suggests that it may target PPP4c to this location. Native 450 kDa and 600 kDa PPP4 complexes are inactive, but can be activated by basic proteins, suggesting that PPP4R2 may also regulate the activity of PPP4c at centrosomal microtubule organising centres.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2) ELISA Kit Customized Service Offer
  1. "A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres."Biochem. J. 347:845-855(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Protein phosphatase 4 interacts with the survival of motor neurons complex and enhances the temporal localisation of snRNPs."J. Cell Sci. 116:1905-1913(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication."Mol. Cell 31:33-46(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination."Nat. Struct. Mol. Biol. 17:365-372(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]