≡

Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1)

[Edit]

DNCLI1; DLC-A; Dynein light chain A; Dynein light intermediate chain 1, cytosolic

Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1)
CCC Q713
HGNC 18745
MGI 2135610
PubMed 21471385
RGD 71072
UniProt Q9Y6G9
Wiki DYNC1LI1
DYNC1LI1 was cloned from rat and found to have a P-loop motif, which is one of the major conserved motifs making up the nucleotide-binding domain found in numerous proteins, including ATPases and kinases. DYNC1LI1, however, lacks other essential motifs associated with ATPase activity, which itself has not been assayed. DYNC1LI and its phospho-isoform are exclusively found with dynein in the slow component of axonal transport in rat optic nerves . In HeLa cells, DYNC1LI1 localizes to the microtubule organizing centre and mitotic spindle, co-localizing with the GTPase Rab4a; thus DYNC1LI1 may be implicated in the regulation of membrane-receptor recycling. In the chicken DYNC1LI1 has been called DLC-A, as part of the DLC-A group of light chains.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynein, Cytoplasmic 1, Light Intermediate Chain 1 (DYNC1LI1) ELISA Kit Customized Service Offer
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  3. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint."EMBO J. 28:902-914(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Adenovirus transport via direct interaction of cytoplasmic dynein with the viral capsid hexon subunit."Cell Host Microbe 6:523-535(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]