G Protein Coupled Receptor 110 (GPR110)

GPR110 is an orphan G protein-coupled receptor--a receptor without a known ligand, a known signaling pathway, or a known function. Despite the lack of information, one can assume that orphan receptors have important biological roles. This prompted us to study the potential isoforms that can be gleaned from known GPR110 transcripts, and the expression of these isoforms in normal and transformed human tissues.

GPR110 is greatly overexpressed in human lung and prostate cancers. GPR110 was overexpressed in 20 of 27 (74%) lung adenocarcinoma tissue cores and in 17 of 29 (59%) prostate adenocarcinoma tissue cores. The GPR110 protein contains two protein domains where cleavage can potentially occur: the SEA domain and the GPS domain.