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Chromodomain Helicase DNA Binding Protein 6 (CHD6)

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RIGB; CHD5; Radiation-induced gene B protein; ATP-dependent helicase CHD6

Chromodomain Helicase DNA Binding Protein 6 (CHD6)
CCC Q731
HGNC 19057
MGI 1918639
PubMed 23408615
RGD 1310465
UniProt Q8TD26
Chromosomal DNA of eukaryotic cells is compacted by nuclear proteins to form chromatin, an organized nucleoprotein structure that can inhibit gene expression. Several multisubunit protein complexes exist to remodel the chromatin to allow patterns of cell type-specific gene expression. CHD6 is thought to be a core member of one or more of these complexes. The encoded protein, which is a member of the SNF2/RAD54 helicase family, contains two chromodomains, a helicase domain, and an ATPase domain.
Chd6 is ubiquitously expressed in both mouse and human, with the highest levels of expression in the brain. The Chd6 gene contains 37 exons, of which exons 12-19 encode the highly conserved ATPase domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromodomain Helicase DNA Binding Protein 6 (CHD6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromodomain Helicase DNA Binding Protein 6 (CHD6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 6 (CHD6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromodomain Helicase DNA Binding Protein 6 (CHD6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromodomain Helicase DNA Binding Protein 6 (CHD6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromodomain Helicase DNA Binding Protein 6 (CHD6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromodomain Helicase DNA Binding Protein 6 (CHD6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 6 (CHD6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromodomain Helicase DNA Binding Protein 6 (CHD6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromodomain Helicase DNA Binding Protein 6 (CHD6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Chromodomain Helicase DNA Binding Protein 6 (CHD6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Chromodomain Helicase DNA Binding Protein 6 (CHD6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Chromodomain Helicase DNA Binding Protein 6 (CHD6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Chromodomain Helicase DNA Binding Protein 6 (CHD6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Chromodomain Helicase DNA Binding Protein 6 (CHD6) ELISA Kit Customized Service Offer
  1. "CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases."Mamm. Genome 13:117-119(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "cDNA cloning and transcriptional controlling of a novel radiation-induced gene and its function analysis."Zhonghua Fang She Yi Xue Yu Fang Hu Za Zhi 22:73-77(2002)
  5. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  8. "The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation."Mol. Cell. Biol. 25:10895-10906(2005) [PubMed] [Europe PMC] [Abstract]
  9. "CHD6 is a DNA-dependent ATPase and localizes at nuclear sites of mRNA synthesis."FEBS Lett. 580:5851-5857(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Disruption of the TCF4 gene in a girl with mental retardation but without the classical Pitt-Hopkins syndrome."Am. J. Med. Genet. A 146A:2053-2059(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Solution structure of chromo domain 2 in chromodomain-helicase-DNA-binding protein 6."Submitted (OCT-2007) to the PDB data bank