Potassium Channel Subfamily K, Member 18 (KCNK18)

Using DNA samples from multiple generations of a large family with Migraine with aura, the researchers were able to identify the mutation on a gene known as KCNK18 or TRESK that was common to the members of the family. It's believed that this mutation alters the electrical activity in certain brain cells.

TRESK impacts the K2P (potassium) channels through out the nervous system. The K2P channels play a key role in the excitability of neurons in the brain. They're also a target for many anesthetics and neuroprotective agents and have been implicated in several pain pathways in the brain.1 This may provide a lead to developing new treatments and may be a clue to why some medications now in use for Migraine prevention work for some Migraineurs.