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FRY belongs to the furry protein family. Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching. May function as a transcriptional activator.
A transcriptional corepressor, Xenopus furry (Xfurry), is expressed in the chordamesodermal region and induces secondary dorsal axes when overexpressed on the ventral side of the embryo. The N-terminal furry domain functions as a repressor, and the C-terminal leucine zipper (LZ) motifs /coiled-coil structure, found only in vertebrate homologs, contributes to the nuclear localization.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Furry Homolog (FRY) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Furry Homolog (FRY) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Furry Homolog (FRY) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Furry Homolog (FRY) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Furry Homolog (FRY) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Furry Homolog (FRY) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Furry Homolog (FRY) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Furry Homolog (FRY) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Furry Homolog (FRY) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Furry Homolog (FRY) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Furry Homolog (FRY) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Furry Homolog (FRY) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Furry Homolog (FRY) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Furry Homolog (FRY) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Furry Homolog (FRY) | ELISA Kit Customized Service Offer |
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- "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
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- "Furry protein promotes Aurora A-mediated polo-like kinase 1 activation."J. Biol. Chem. 287:27670-27681(2012) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]