Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures.
HIST2H3A is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPQ849Hu01 | Recombinant Histone Cluster 2, H3a (HIST2H3A) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAQ849Hu01 | Polyclonal Antibody to Histone Cluster 2, H3a (HIST2H3A) | WB,IHC |
Assay Kits | SEQ849Hu | ELISA Kit for Histone Cluster 2, H3a (HIST2H3A) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPQ849Mu01 | Recombinant Histone Cluster 2, H3a (HIST2H3A) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAQ849Mu01 | Polyclonal Antibody to Histone Cluster 2, H3a (HIST2H3A) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Histone Cluster 2, H3a (HIST2H3A) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Histone Cluster 2, H3a (HIST2H3A) | ELISA Kit Customized Service Offer |
Organism species: Chicken (Gallus)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPQ849Ga01 | Recombinant Histone Cluster 2, H3a (HIST2H3A) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAQ849Ga01 | Polyclonal Antibody to Histone Cluster 2, H3a (HIST2H3A) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Histone Cluster 2, H3a (HIST2H3A) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Histone Cluster 2, H3a (HIST2H3A) | ELISA Kit Customized Service Offer |
- "The human and mouse replication-dependent histone genes."Genomics 80:487-498(2002) [PubMed] [Europe PMC] [Abstract]
- "Functional characterization of a human histone gene cluster duplication."Gene 342:35-40(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Modifications of human histone H3 variants during mitosis."Biochemistry 44:13202-13213(2005) [PubMed] [Europe PMC] [Abstract]
- "Identification of a novel phosphorylation site on histone H3 coupled with mitotic chromosome condensation."J. Biol. Chem. 274:25543-25549(1999) [PubMed] [Europe PMC] [Abstract]
- "Human spleen histone H3. Isolation and amino acid sequence."J. Biochem. 90:1205-1211(1981) [PubMed] [Europe PMC] [Abstract]
- "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins."Nature 410:116-120(2001) [PubMed] [Europe PMC] [Abstract]
- "Aurora-B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation."Genes Cells 7:11-17(2002) [PubMed] [Europe PMC] [Abstract]
- "Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase."Nucleic Acids Res. 31:878-885(2003) [PubMed] [Europe PMC] [Abstract]
- "Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1."J. Biol. Chem. 279:54348-54357(2004) [PubMed] [Europe PMC] [Abstract]
- "Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks."Nature 432:406-411(2004) [PubMed] [Europe PMC] [Abstract]
- "Human PAD4 regulates histone arginine methylation levels via demethylimination."Science 306:279-283(2004) [PubMed] [Europe PMC] [Abstract]
- "The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment."Genes Dev. 19:472-488(2005) [PubMed] [Europe PMC] [Abstract]
- "Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha."J. Biol. Chem. 280:13545-13553(2005) [PubMed] [Europe PMC] [Abstract]
- "Expression patterns and post-translational modifications associated with mammalian histone H3 variants."J. Biol. Chem. 281:559-568(2006) [PubMed] [Europe PMC] [Abstract]
- "Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage."Mol. Cell 22:383-394(2006) [PubMed] [Europe PMC] [Abstract]
- "Quantitative proteomic analysis of post-translational modifications of human histones."Mol. Cell. Proteomics 5:1314-1325(2006) [PubMed] [Europe PMC] [Abstract]
- "Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17."Mol. Endocrinol. 20:1562-1573(2006) [PubMed] [Europe PMC] [Abstract]
- "Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4."Proc. Natl. Acad. Sci. U.S.A. 103:5291-5296(2006) [PubMed] [Europe PMC] [Abstract]
- "PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation."Genes Dev. 21:3369-3380(2007) [PubMed] [Europe PMC] [Abstract]
- "Organismal differences in post-translational modifications in histones H3 and H4."J. Biol. Chem. 282:7641-7655(2007) [PubMed] [Europe PMC] [Abstract]
- "Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification."J. Biol. Chem. 282:7632-7640(2007) [PubMed] [Europe PMC] [Abstract]
- "Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive."Nature 449:933-937(2007) [PubMed] [Europe PMC] [Abstract]
- "Arginine methylation of the histone H3 tail impedes effector binding."J. Biol. Chem. 283:3006-3010(2008) [PubMed] [Europe PMC] [Abstract]
- "Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation."Nat. Cell Biol. 10:53-60(2008) [PubMed] [Europe PMC] [Abstract]
- "Acetylation of histone H3 at the nucleosome dyad alters DNA-histone binding."J. Biol. Chem. 284:23312-23321(2009) [PubMed] [Europe PMC] [Abstract]
- "JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin."Nature 461:819-822(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
- "Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers."Cell 142:967-980(2010) [PubMed] [Europe PMC] [Abstract]
- "Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4."Nature 464:792-796(2010) [PubMed] [Europe PMC] [Abstract]
- "Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification."Cell 146:1016-1028(2011) [PubMed] [Europe PMC] [Abstract]
- "Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA."Mol. Cell 46:7-17(2012) [PubMed] [Europe PMC] [Abstract]
- "Lysyl oxidase-like 2 deaminates lysine 4 in histone H3."Mol. Cell 46:369-376(2012) [PubMed] [Europe PMC] [Abstract]
- "Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer."Cell 152:859-872(2013) [PubMed] [Europe PMC] [Abstract]
- "Structure of the histone chaperone ASF1 bound to the histone H3 C-terminal helix and functional insights."Structure 15:191-199(2007) [PubMed] [Europe PMC] [Abstract]