≡

Anoctamin 9 (ANO9)

[Edit]

PIG5; TP53I5; TMEM16J; Tumor Protein p53 Inducible Protein 5; Transmembrane Protein 16J

Anoctamin 9 (ANO9)
CCC Q868
HGNC 20679
MGI 1918595
PubMed 20964844
UniProt A1A5B4
ANO9 belongs to the anoctamin family. The anoctamin proteins represent a novel family of membrane proteins with 10 members (ano1-10) in mammals. Some members are over-expressed in various cancers and diseases. Anoctamins are highly hydrophobic proteins with eight transmembrane domains (TMD) and one re-entry loop. Anoctamin proteins have tissue-specific patterns of expression. Although electrophysiological and biochemical studies in both native and heterologous expression systems provided important clues to understanding the function of anoctamin membrane proteins, the biological roles have been elucidated for only a few members of this family. It seems that not all anoctamin proteins operate as Ca2+-activated Cl- channels, since ano9 and ano10 inhibited anion conductance produced by ano1.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anoctamin 9 (ANO9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anoctamin 9 (ANO9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anoctamin 9 (ANO9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anoctamin 9 (ANO9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anoctamin 9 (ANO9) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anoctamin 9 (ANO9) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anoctamin 9 (ANO9) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anoctamin 9 (ANO9) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anoctamin 9 (ANO9) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anoctamin 9 (ANO9) ELISA Kit Customized Service Offer
  1. "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."DNA Res. 10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Expression and function of epithelial anoctamins."J. Biol. Chem. 285:7838-7845(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?"Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract]
  7. "CFTR and TMEM16A are separate but functionally related Cl-channels."Cell. Physiol. Biochem. 28:715-724(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Anoctamins."Pflugers Arch. 462:195-208(2011) [PubMed] [Europe PMC] [Abstract]
  9. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
  10. "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels."Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Anoctamins are a family of Ca2+ activated Cl- channels."J. Cell Sci. 125:4991-4998(2012) [PubMed] [Europe PMC] [Abstract]