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Thioredoxin Domain Containing Protein 5 (TXNDC5)

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EndoPDI; Hcc-2; ERp46; PDIA15; TLP46; Protein Disulfide Isomerase Family A, Member 15; Endoplasmic reticulum resident protein 46; Thioredoxin-like protein p46

Thioredoxin Domain Containing Protein 5 (TXNDC5)
CCC Q914
HGNC 21073
MGI 2145316
PubMed 24023338
UniProt Q8NBS9
Wiki TXNDC5
TXNDC5 encodes a protein-disulfide isomerase. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. This gene can be co-transcribed with the upstream gene MU.
Vitiligo is a pigmentary skin disorder characterized by a chronic and progressive loss of melanocytes. Although the aetiology of vitiligo is currently unknown, several theories have been proposed to explain the pathogenesis of this disease, including autoimmune, neural, self-destruction, oxidative stress, and genetic theories. Thioredoxin domain containing 5 (TXNDC5) is a newly identified member of the thioredoxin family. TXNDC5 has a protein disulphide isomerase-like domain which plays an important role in protein folding and chaperone activity, against endoplasmic reticulum (ER) stress induced by oxidative stress within the ER.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thioredoxin Domain Containing Protein 5 (TXNDC5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thioredoxin Domain Containing Protein 5 (TXNDC5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thioredoxin Domain Containing Protein 5 (TXNDC5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thioredoxin Domain Containing Protein 5 (TXNDC5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thioredoxin Domain Containing Protein 5 (TXNDC5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Thioredoxin Domain Containing Protein 5 (TXNDC5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Thioredoxin Domain Containing Protein 5 (TXNDC5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Thioredoxin Domain Containing Protein 5 (TXNDC5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Thioredoxin Domain Containing Protein 5 (TXNDC5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Thioredoxin Domain Containing Protein 5 (TXNDC5) ELISA Kit Customized Service Offer
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  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  7. "The solution structure of the third thioredoxin domain of human thioredoxin domain-containing protein 5."Submitted (SEP-2006) to the PDB data bank