Ras Homolog Enriched In Brain Like Protein 1 (RHEBL1)

The Ras family of small GTPases regulates a wide variety of cellular functions that include cell growth, differentiation, and transformation. RHEBL1 belonging to the Rheb branch of small GTPase proteins. The cDNA sequence contains an open reading frame of 551 bp, encoding a putative protein of 183 aminoacid residues. The expression pattern of RHEBL1 showed that it was ubiquitously expressed in 17 tissues. RHEBL1 gene encodes a 20.69kDa protein, localized in cytoplasm when overexpressed in COS7 cells. Reporter gene assays showed that overexpression of RHEBL1 in HEK 293T cells strongly activated the transcriptional activities of NF-kappa B, while the mutant (D60K) only weakly activates NF-kappa B-mediated transcription. RHEBL1 is a positive regulator of NF-kappa B-mediated gene transcription.