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Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1)

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HPIP; Pre-B-cell Leukemia Transcription Factor Interacting Protein 1; Hematopoietic PBX-interacting protein

Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1)
CCC Q927
HGNC 21199
MGI 2441670
RGD 1305180
UniProt Q96AQ6
PBXIP1 is a regulator of pre-B-cell leukemia transcription factors (BPXs) function. It inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. PBXIP1 also tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling.
HPIP is mainly localized in the cytosol and in small amounts in the nucleus. The region of PBX that interacts with HPIP includes both the homeodomain and immediate N-terminal flanking sequences. Strikingly, electrophoretic mobility shift assays revealed that HPIP inhibits the ability of PBX-HOX heterodimers to bind to target sequences. Moreover, HPIP strongly inhibits the transactivation activity of E2A-PBX. Together these findings suggest that HPIP is a new regulator of PBX function.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Pre-B-cell Leukemia Homeobox Interacting Protein 1 (PBXIP1) ELISA Kit Customized Service Offer
  1. "Functional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNA."J. Biol. Chem. 275:26172-26177(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Functional characterization of multiple domains involved in the subcellular localization of the hematopoietic Pbx interacting protein (HPIP)."Oncogene 21:6766-6771(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "An inherent role of microtubule network in the action of nuclear receptor."Proc. Natl. Acad. Sci. U.S.A. 103:15981-15986(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]