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Peptidase Inhibitor 16 (PI16)

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MSMBBP; CRISP9; PSPBP; Microseminoprotein, Beta-Binding Protein; Protease Inhibitor 16; PSP94-binding protein; Cysteine-rich secretory protein 9

Peptidase Inhibitor 16 (PI16)
CCC Q943
HGNC 21245
MGI 1921366
RGD 1304760
UniProt Q6UXB8
PI16 is a putative serine protease inhibitor. PI16 may serve as a marker following prostatectomy for prostate cancer. This protein binds with high affinity to PSP94.
PI16 expression is enhanced after serum stimulation of primary cardiomyocytes and is rapidly secreted into the conditioned medium of cardiomyocytes. PI16 is overexpressed in the hypertrophic and failing heart and inhibits cardiomyocyte growth. Suppression of endogenous PI16 expression in primary cardiomyocytes significantly enhances cardiomyocyte size. Transgenic mice overexpressing PI16 in a cardiomyocyte-specific manner show normal cardiac function but have smaller hearts with hypotrophic cardiomyocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ943Hu01 Recombinant Peptidase Inhibitor 16 (PI16) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAQ943Hu01 Polyclonal Antibody to Peptidase Inhibitor 16 (PI16) WB; IHC; ICC; IP.
LAQ943Hu71 Biotin-Linked Polyclonal Antibody to Peptidase Inhibitor 16 (PI16) WB; IHC; ICC.
MAQ943Hu21 Monoclonal Antibody to Peptidase Inhibitor 16 (PI16) WB; IHC; ICC; IP.
MAQ943Hu22 Monoclonal Antibody to Peptidase Inhibitor 16 (PI16) WB; IHC; ICC; IP.
MAQ943Hu23 Monoclonal Antibody to Peptidase Inhibitor 16 (PI16) WB; IHC; ICC; IP.
Assay Kits SEQ943Hu ELISA Kit for Peptidase Inhibitor 16 (PI16) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ943Mu01 Recombinant Peptidase Inhibitor 16 (PI16) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAQ943Mu01 Polyclonal Antibody to Peptidase Inhibitor 16 (PI16) WB; IHC; ICC; IP.
LAQ943Mu71 Biotin-Linked Polyclonal Antibody to Peptidase Inhibitor 16 (PI16) WB; IHC; ICC.
Assay Kits SEQ943Mu ELISA Kit for Peptidase Inhibitor 16 (PI16) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peptidase Inhibitor 16 (PI16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peptidase Inhibitor 16 (PI16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peptidase Inhibitor 16 (PI16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peptidase Inhibitor 16 (PI16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidase Inhibitor 16 (PI16) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ943Bo01 Recombinant Peptidase Inhibitor 16 (PI16) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAQ943Bo01 Polyclonal Antibody to Peptidase Inhibitor 16 (PI16) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Peptidase Inhibitor 16 (PI16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidase Inhibitor 16 (PI16) ELISA Kit Customized Service Offer
  1. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids."Biochem. J. 385:105-114(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Prognostic value of prostate secretory protein of 94 amino acids and its binding protein after radical prostatectomy."Clin. Cancer Res. 12:6018-6022(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."Mol. Cell. Proteomics 0:0-0(2011) [PubMed] [Europe PMC] [Abstract]