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EPS8 Like Protein 2 (EPS8L2)

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EPS8R2 Epidermal Growth Factor Receptor Kinase Substrate 8-Like Protein 2; Epidermal growth factor receptor pathway substrate 8-related protein 2

EPS8 Like Protein 2 (EPS8L2)
CCC Q947
HGNC 21296
MGI 2138828
PubMed 14565974
RGD 1310912
UniProt Q9H6S3
Wiki EPS8L2
EPS8L2 encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling.
EPS8 codes for a protein essential in Ras to Rac signaling leading to actin remodeling. Three genes highly homologous to EPS8 were discovered, thereby defining a novel gene family. The mouse fragments were manually assembled, and the organization of both human and mouse genes was reconstructed. The gene structures in Celera annotations of the human and mouse genomes were compared to outline correspondences and divergences.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant EPS8 Like Protein 2 (EPS8L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to EPS8 Like Protein 2 (EPS8L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to EPS8 Like Protein 2 (EPS8L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for EPS8 Like Protein 2 (EPS8L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for EPS8 Like Protein 2 (EPS8L2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant EPS8 Like Protein 2 (EPS8L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to EPS8 Like Protein 2 (EPS8L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to EPS8 Like Protein 2 (EPS8L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for EPS8 Like Protein 2 (EPS8L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for EPS8 Like Protein 2 (EPS8L2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant EPS8 Like Protein 2 (EPS8L2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to EPS8 Like Protein 2 (EPS8L2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to EPS8 Like Protein 2 (EPS8L2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for EPS8 Like Protein 2 (EPS8L2) CLIA Kit Customized Service Offer
n/a ELISA Kit for EPS8 Like Protein 2 (EPS8L2) ELISA Kit Customized Service Offer
  1. "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure."Genomics 81:234-244(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway."Mol. Biol. Cell 15:91-98(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "solution structure of the SH3 domain from human epidermal growth factor receptor pathway substrate 8-like protein."Submitted (JUL-2005) to the PDB data bank