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Interferon Regulatory Factor 2 Binding Protein 1 (IRF2BP1)

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IRF2-BP1; Probable E3 ubiquitin-protein ligase IRF2BP1

Interferon Regulatory Factor 2 Binding Protein 1 (IRF2BP1)
CCC Q989
HGNC 21728
MGI 2442159
PubMed 21444724
RGD 1308312
UniProt Q8IU81
IRF2BP1 belongs to the IRF2BP family and acts as a transcriptional repressor and co-repressor in a IRF2-dependent manner. It contains a C-terminal RING-type zinc finger domain necessary for interaction with BAP1. Jun-dimerization protein 2 (JDP2) is a member of the activating protein-1 (AP-1) family of transcription factors.
Interferon regulatory factor-2-binding protein-1 (IRF2-BP1), which is reported to be a transcriptional corepressor of IRF2, was isolated as a JDP2-binding protein using an epitope-tagging method. As anticipated from the presence of a RING-finger domain, IRF2-BP1 enhanced the polyubiquitination of JDP2. Moreover, IRF2-BP1 repressed ATF2-mediated transcriptional activation from a CRE-containing promoter.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Regulatory Factor 2 Binding Protein 1 (IRF2BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Regulatory Factor 2 Binding Protein 1 (IRF2BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Regulatory Factor 2 Binding Protein 1 (IRF2BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Regulatory Factor 2 Binding Protein 1 (IRF2BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Regulatory Factor 2 Binding Protein 1 (IRF2BP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Regulatory Factor 2 Binding Protein 1 (IRF2BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Regulatory Factor 2 Binding Protein 1 (IRF2BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Regulatory Factor 2 Binding Protein 1 (IRF2BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Regulatory Factor 2 Binding Protein 1 (IRF2BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Regulatory Factor 2 Binding Protein 1 (IRF2BP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Regulatory Factor 2 Binding Protein 1 (IRF2BP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Regulatory Factor 2 Binding Protein 1 (IRF2BP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Regulatory Factor 2 Binding Protein 1 (IRF2BP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Regulatory Factor 2 Binding Protein 1 (IRF2BP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Regulatory Factor 2 Binding Protein 1 (IRF2BP1) ELISA Kit Customized Service Offer
  1. "Identification of novel co-repressor molecules for interferon regulatory factor-2."Nucleic Acids Res. 31:3016-3026(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription."FEBS Lett. 582:2833-2837(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]