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Interferon Regulatory Factor 2 Binding Protein 2 (IRF2BP2)

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IRF2-BP2

Interferon Regulatory Factor 2 Binding Protein 2 (IRF2BP2)
CCC Q990
HGNC 21729
MGI 2443921
UniProt Q7Z5L9
IRF2BP2 encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. IRF-2BP1 and IRF-2BP2A/B contain an N-terminal zinc finger and a C-terminal RING finger domain of the C3HC4 subclass, but show no homology to other known transcriptional regulators; they therefore define a new family of co- repressor proteins.
IRF2BP2 interacts with NFAT1 and repress its transcriptional activity, suggesting that IRF2BP2 can be a new regulator of NFAT1 transcriptional activity. IRF2BP2 has an impact on the cellular stress response after Act.D treatment and that it diminishes the induction of apoptosis after doxorubicin treatment.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Regulatory Factor 2 Binding Protein 2 (IRF2BP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Regulatory Factor 2 Binding Protein 2 (IRF2BP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Regulatory Factor 2 Binding Protein 2 (IRF2BP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Regulatory Factor 2 Binding Protein 2 (IRF2BP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Regulatory Factor 2 Binding Protein 2 (IRF2BP2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Interferon Regulatory Factor 2 Binding Protein 2 (IRF2BP2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Interferon Regulatory Factor 2 Binding Protein 2 (IRF2BP2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Interferon Regulatory Factor 2 Binding Protein 2 (IRF2BP2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Interferon Regulatory Factor 2 Binding Protein 2 (IRF2BP2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Interferon Regulatory Factor 2 Binding Protein 2 (IRF2BP2) ELISA Kit Customized Service Offer
  1. "Identification of novel co-repressor molecules for interferon regulatory factor-2."Nucleic Acids Res. 31:3016-3026(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression."FASEB J. 24:4825-4834(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity."Mol. Cell. Biol. 31:2889-2901(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2."PLoS ONE 6:E24100-E24100(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]