≡

AarF Domain Containing Kinase 4 (ADCK4)

[Edit]

AarF Domain Containing Kinase 4 (ADCK4)
CCC Q994
HGNC 19041
MGI 1924139
PubMed 24270414
RGD 1311356
UniProt Q96D53
ADCK4 is a member of group i collagen (fibrillar forming collagen). The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr). There are 2 named isoforms produced by alternative splicing.
The ADCK family comprises five paralogs in human (ADCK1-5). ADCK3 and ADCK4 are highly similar and appear to result from a gene duplication in vertebrates. In contrast, ADCK1, 2, and 5 have split from ADCK3 and 4 very early during evolution because all eukaryotes and several, but not all, gram-negative bacteria possess at least one representative of each subgroup. Yeast ABC1/Coq8 is the ortholog of ADCK3 and 4, whereas bacterial UbiB is more similar to the ADCK1–ADCK5 subgroup.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AarF Domain Containing Kinase 4 (ADCK4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AarF Domain Containing Kinase 4 (ADCK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AarF Domain Containing Kinase 4 (ADCK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AarF Domain Containing Kinase 4 (ADCK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for AarF Domain Containing Kinase 4 (ADCK4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AarF Domain Containing Kinase 4 (ADCK4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AarF Domain Containing Kinase 4 (ADCK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AarF Domain Containing Kinase 4 (ADCK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AarF Domain Containing Kinase 4 (ADCK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for AarF Domain Containing Kinase 4 (ADCK4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant AarF Domain Containing Kinase 4 (ADCK4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to AarF Domain Containing Kinase 4 (ADCK4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to AarF Domain Containing Kinase 4 (ADCK4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for AarF Domain Containing Kinase 4 (ADCK4) CLIA Kit Customized Service Offer
n/a ELISA Kit for AarF Domain Containing Kinase 4 (ADCK4) ELISA Kit Customized Service Offer
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  4. "A Gly-zipper motif mediates homodimerization of the transmembrane domain of the mitochondrial kinase ADCK3."J. Am. Chem. Soc. 136:14068-14077(2014) [PubMed] [Europe PMC] [Abstract]
  5. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
  6. "ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption." J. Clin. Invest. 123:5179-5189(2013) [PubMed] [Europe PMC] [Abstract]