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Ubinuclein 2 (UBN2)

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Ubinuclein 2 (UBN2)
CCC R007
HGNC 21931
MGI 2444236
RGD 1310722
UniProt Q6ZU65
Formation of SAHF in human cells is driven by a complex of histone chaperones, namely, HIRA and ASF1a. In yeast, the complex orthologous to HIRA/ASF1a contains two additional proteins, Hpc2p and Hir3p. Using a sophisticated approach to search for remote orthologs conserved in multiple species through evolution, identified the HIRA-associated proteins, UBN1 and UBN2, as candidate human orthologs of Hpc2p. Hpc2-related domain of UBN1, UBN2, and Hpc2p is an evolutionarily conserved HIRA/Hir-binding domain, which directly interacts with the N-terminal WD repeats of HIRA/Hir. UBN1 binds to proliferation-promoting genes that are repressed by SAHF and associates with histone methyltransferase activity that methylates lysine 9 of histone H3, a site that is methylated in SAHF. UBN1 is indispensable for formation of SAHF.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubinuclein 2 (UBN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubinuclein 2 (UBN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubinuclein 2 (UBN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubinuclein 2 (UBN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubinuclein 2 (UBN2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubinuclein 2 (UBN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubinuclein 2 (UBN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubinuclein 2 (UBN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubinuclein 2 (UBN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubinuclein 2 (UBN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubinuclein 2 (UBN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubinuclein 2 (UBN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubinuclein 2 (UBN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubinuclein 2 (UBN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubinuclein 2 (UBN2) ELISA Kit Customized Service Offer
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