TMC4 belongs to the TMC family. cDNAs spanning the full length of the predicted open reading frames of the mammalian genes were cloned and sequenced. All are strongly predicted to encode proteins with 6 to 10 transmembrane domains and a novel conserved 120-amino-acid sequence that termed the TMC domain. TMC1, TMC2, and TMC3 comprise a distinct subfamily expressed at low levels, whereas TMC4 to TMC8 are expressed at higher levels in multiple tissues. . TMC6 and TMC8 are identical to the EVER1 and EVER2 genes implicated in epidermodysplasia verruciformis, a recessive disorder comprising susceptibility to cutaneous human papilloma virus infections and associated nonmelanoma skin cancers, providing additional genetic and tissue systems in which to study the TMC gene family.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPR052Hu01 | Recombinant Transmembrane Channel Like Protein 4 (TMC4) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | n/a | Monoclonal Antibody to Transmembrane Channel Like Protein 4 (TMC4) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Transmembrane Channel Like Protein 4 (TMC4) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Transmembrane Channel Like Protein 4 (TMC4) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Transmembrane Channel Like Protein 4 (TMC4) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Transmembrane Channel Like Protein 4 (TMC4) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Transmembrane Channel Like Protein 4 (TMC4) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Transmembrane Channel Like Protein 4 (TMC4) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Transmembrane Channel Like Protein 4 (TMC4) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Transmembrane Channel Like Protein 4 (TMC4) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Transmembrane Channel Like Protein 4 (TMC4) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Transmembrane Channel Like Protein 4 (TMC4) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Transmembrane Channel Like Protein 4 (TMC4) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for Transmembrane Channel Like Protein 4 (TMC4) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Transmembrane Channel Like Protein 4 (TMC4) | ELISA Kit Customized Service Offer |
- "TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins."BMC Genomics 4:24-24(2003) [PubMed] [Europe PMC] [Abstract]
- "Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis."Genomics 82:300-308(2003) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]