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Apoptosis Related Protein 3 (APR3)

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C2orf28; HSPC013; p18; All-trans retinoic acid-induced differentiation factor

Apoptosis Related Protein 3 (APR3)
CCC R178
HGNC 24090
MGI 1918918
PubMed 11042152
RGD 1311605
UniProt Q6UW56
Wiki C2orf28
APR3 is thought to be involved in apoptosis, and may also be involved in hematopoietic development and differentiation. The use of alternative splice sites and promotors result in multiple transcript variants encoding different isoforms.
Three hundred cDNAs containing putatively entire open reading frames (ORFs) for previously undefined genes were obtained from CD34+ hematopoietic stem/progenitor cells (HSPCs), based on EST cataloging, clone sequencing, in silico cloning, and rapid amplification of cDNA ends (RACE). The cDNA sizes ranged from 360 to 3496 bp and their ORFs coded for peptides of 58-752 amino acids. Public database search indicated that 225 cDNAs exhibited sequence similarities to genes identified across a variety of species.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apoptosis Related Protein 3 (APR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apoptosis Related Protein 3 (APR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apoptosis Related Protein 3 (APR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apoptosis Related Protein 3 (APR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apoptosis Related Protein 3 (APR3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apoptosis Related Protein 3 (APR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apoptosis Related Protein 3 (APR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apoptosis Related Protein 3 (APR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apoptosis Related Protein 3 (APR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apoptosis Related Protein 3 (APR3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Apoptosis Related Protein 3 (APR3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Apoptosis Related Protein 3 (APR3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Apoptosis Related Protein 3 (APR3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Apoptosis Related Protein 3 (APR3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Apoptosis Related Protein 3 (APR3) ELISA Kit Customized Service Offer
  1. "Improved PCR-based subtractive hybridization strategy for cloning differentially expressed genes."BioTechniques 29:310-313(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Apoptosis related protein 3, an ATRA-upregulated membrane protein arrests the cell cycle at G1/S phase by decreasing the expression of cyclin D1."Biochem. Biophys. Res. Commun. 358:1041-1046(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of the distinct promoters for the two transcripts of apoptosis related protein 3 and their transcriptional regulation by NFAT and NFkappaB."Mol. Cell. Biochem. 302:187-194(2007) [PubMed] [Europe PMC] [Abstract]
  10. "NELL-1 binds to APR3 affecting human osteoblast proliferation and differentiation."FEBS Lett. 585:2410-2418(2011) [PubMed] [Europe PMC] [Abstract]