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Serrate (SRRT)

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Asr2; ARS2; Arsenite Resistance Protein 2; Serrate RNA Effector Molecule Homolog

Serrate (SRRT)
CCC R180
HGNC 24101
MGI 1933527
UniProt Q9BXP5
SRRT belongs to the ARS2 family. Interacts with NCBP1/CBP80 and RNASEN By similarity. Interacts with CASP8AP2/FLASH.
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and RNASEN, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serrate (SRRT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serrate (SRRT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serrate (SRRT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serrate (SRRT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serrate (SRRT) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serrate (SRRT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serrate (SRRT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serrate (SRRT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serrate (SRRT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serrate (SRRT) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Serrate (SRRT) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Serrate (SRRT) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Serrate (SRRT) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Serrate (SRRT) CLIA Kit Customized Service Offer
n/a ELISA Kit for Serrate (SRRT) ELISA Kit Customized Service Offer
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  9. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  12. "ARS2 is a conserved eukaryotic gene essential for early mammalian development."Mol. Cell. Biol. 28:1503-1514(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation."Cell 138:328-339(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase."Mol. Cell. Biol. 29:4729-4741(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways."Mol. Cancer Res. 8:1388-1398(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  21. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  22. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]