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La Ribonucleoprotein Domain Family, Member 4 (LARP4)

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La Related Protein 4

La Ribonucleoprotein Domain Family, Member 4 (LARP4)
CCC R222
HGNC 24320
MGI 2443114
PubMed 12477932
UniProt Q71RC2
Wiki LARP4
LARP4 can bind poly(A) RNA and interact with poly(A) binding protein (PABP). LARP4 interacts with RACK1, a 40S ribosome- and mRNA-associated protein. LARP4 cosediments with 40S ribosome subunits and polyribosomes, and its knockdown decreases translation. Mutagenesis of the RNA binding or PABP interaction motifs decrease LARP4 association with polysomes. LARP4 contains a variant PAM2 with tryptophan (PAM2w) in place of the phenylalanine. A cocrystal of PABC bound to LARP4 PAM2w shows tryptophan in the pocket in PABC-MLLE otherwise occupied by phenylalanine. LARP4 expression stimulates luciferase reporter activity by promoting mRNA stability, as shown by mRNA decay analysis of luciferase and cellular mRNAs. LARP4 activity is integrated with other PAM2-protein activities by PABP as part of mRNA homeostasis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant La Ribonucleoprotein Domain Family, Member 4 (LARP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to La Ribonucleoprotein Domain Family, Member 4 (LARP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to La Ribonucleoprotein Domain Family, Member 4 (LARP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for La Ribonucleoprotein Domain Family, Member 4 (LARP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for La Ribonucleoprotein Domain Family, Member 4 (LARP4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant La Ribonucleoprotein Domain Family, Member 4 (LARP4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to La Ribonucleoprotein Domain Family, Member 4 (LARP4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to La Ribonucleoprotein Domain Family, Member 4 (LARP4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for La Ribonucleoprotein Domain Family, Member 4 (LARP4) CLIA Kit Customized Service Offer
n/a ELISA Kit for La Ribonucleoprotein Domain Family, Member 4 (LARP4) ELISA Kit Customized Service Offer
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