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WD Repeat Containing Domain Protein 62 (WDR62)

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C19orf14

WD Repeat Containing Domain Protein 62 (WDR62)
CCC R248
HGNC 24502
MGI 1923696
PubMed 22308068
RGD 1306714
UniProt O43379
Wiki WDR62
The WDR62 gene encodes 1,523 amino acids and contains 32 exons. Immunohistochemical staining of human fetal brain at 20 weeks' gestation demonstrated enriched WDR62 expression within the ventricular and subventricular zones. Stainings suggested predominantly nuclear localization, which was confirmed by immunofluorescence microscopy and Western blot analysis.
WDR62 is expressed by neural stem cells and intermediate progenitors, marked by SOX2 and TBR2 expression. Expression of WDR62 in the neocortex is transient, spanning the period of embryonic neurogenesis. Unlike other microcephaly genes, WDR62 apparently does not associate with centrosomes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat Containing Domain Protein 62 (WDR62) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat Containing Domain Protein 62 (WDR62) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat Containing Domain Protein 62 (WDR62) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat Containing Domain Protein 62 (WDR62) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat Containing Domain Protein 62 (WDR62) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat Containing Domain Protein 62 (WDR62) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat Containing Domain Protein 62 (WDR62) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat Containing Domain Protein 62 (WDR62) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat Containing Domain Protein 62 (WDR62) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat Containing Domain Protein 62 (WDR62) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant WD Repeat Containing Domain Protein 62 (WDR62) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to WD Repeat Containing Domain Protein 62 (WDR62) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to WD Repeat Containing Domain Protein 62 (WDR62) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for WD Repeat Containing Domain Protein 62 (WDR62) CLIA Kit Customized Service Offer
n/a ELISA Kit for WD Repeat Containing Domain Protein 62 (WDR62) ELISA Kit Customized Service Offer
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  5. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "WDR62 is associated with the spindle pole and is mutated in human microcephaly."Nat. Genet. 42:1010-1014(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture."Nat. Genet. 42:1015-1020(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations." Nature 467:207-210(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Mutations in WDR62, encoding a centrosomal and nuclear protein, in Indian primary microcephaly families with cortical malformations."Clin. Genet. 80:532-540(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]