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Tectonic 3 (TCTN3)

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TECT3; C10orf61

Tectonic 3 (TCTN3)
CCC R251
HGNC 24519
MGI 1914840
PubMed 22883145
RGD 1305166
UniProt Q6NUS6
Tectonic3 (TCTN3) on chromosome 10 is a promising NTD candidate gene in humans. The Tectonic gene in mice,which is 58% the same to TCTN3 in humans, is crucial for proper neural development. It has yet to be determined what the specific function of TCTN3 is in humans.
The success of this large-scale effort was assessed by a bioinformatics analysis of the proteins through predictions of protein domains, subcellular localizations, and possible functional roles. The SPDI collection should facilitate efforts to better understand intercellular communication, may lead to new understandings of human diseases, and provides potential opportunities for the development of therapeutics.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tectonic 3 (TCTN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tectonic 3 (TCTN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tectonic 3 (TCTN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tectonic 3 (TCTN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tectonic 3 (TCTN3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tectonic 3 (TCTN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tectonic 3 (TCTN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tectonic 3 (TCTN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tectonic 3 (TCTN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tectonic 3 (TCTN3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tectonic 3 (TCTN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tectonic 3 (TCTN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tectonic 3 (TCTN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tectonic 3 (TCTN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tectonic 3 (TCTN3) ELISA Kit Customized Service Offer
  1. "Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition."Genes Dev. 20:22-27(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Identification of novel regulators of apoptosis using a high-throughput cell-based screen."Mol. Cells 23:170-174(2007) [PubMed] [Europe PMC] [Abstract]
  8. "TCTN3 mutations cause Mohr-Majewski syndrome." Am. J. Hum. Genet. 91:372-378(2012) [PubMed] [Europe PMC] [Abstract]