≡

Sialic Acid Binding Ig Like Lectin 16 (SIGLEC16)

[Edit]

Siglec-P16

Sialic Acid Binding Ig Like Lectin 16 (SIGLEC16)
CCC R300
HGNC 24851
PubMed 18629938
UniProt A6NMB1
A cDNA encoding human Siglec-16, currently classed as a pseudogene in the databases (SIGLECP16), is expressed in various cell lines and tissues. A polymorphism screen for the two alleles of SIGLEC16 found their frequencies to be 50% amongst the UK population. A search for donor sequences for SIGLEC16 revealed a subfamily of activating Siglec with charged transmembrane domains predicted to associate with ITAM-encoding adaptor proteins. In support of this, Siglec-16 was expressed at the cell surface in the presence of DAP12, but not the FcRgamma chain.
Siglec-16 expression in CD14(+) tissue macrophages and in normal human brain, cancerous oesophagus and lung. This is the first activating human Siglec receptor found to have functional and non-functional alleles within the population.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sialic Acid Binding Ig Like Lectin 16 (SIGLEC16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sialic Acid Binding Ig Like Lectin 16 (SIGLEC16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sialic Acid Binding Ig Like Lectin 16 (SIGLEC16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sialic Acid Binding Ig Like Lectin 16 (SIGLEC16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sialic Acid Binding Ig Like Lectin 16 (SIGLEC16) ELISA Kit Customized Service Offer
  1. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia."J. Biol. Chem. 277:24466-24474(2002) [PubMed] [Europe PMC] [Abstract]
  4. "SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans."Eur. J. Immunol. 38:2303-2315(2008) [PubMed] [Europe PMC] [Abstract]