Zinc Finger Protein 581 (ZNF581)

ZNF581 belongs to the krueppel C2H2-type zinc-finger protein family. May be involved in transcriptional regulation. The Cys₂His₂-like fold group is by far the best-characterized class of zinc fingers and are extremely common in mammalian transcription factors. This class of zinc fingers can have a variety of functions such as binding RNA and mediating protein-protein interactions, but is best known for its role in sequence specific DNA-binding proteins such as Zif268. In such proteins, individual zinc finger domains typically occur as tandem repeats with two, three, or more fingers comprising the DNA-binding domain of the protein. The α-helix of each domain can make sequence-specific contacts to DNA bases; residues from a single recognition helix can contact 4 or more bases to yield an overlapping pattern of contacts with adjacent zinc fingers.