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Heat Shock Protein Beta 11 (HSPb11)

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C1orf41; PP25; IFT25; Hsp16.2; Placental protein 25; Intraflagellar Transport 25 Homolog; Heat Shock Protein Family B, Member 11

Heat Shock Protein Beta 11 (HSPb11)
CCC R335
HGNC 25019
MGI 1920188
RGD 1596413
UniProt Q9Y547
Heat shock proteins (HSP) were originally identified as stress-responsive proteins required to deal with proteotoxic stresses.
HSPB11 was shown to form oligomeric complexes and to prevent the aggregation of in vitro denaturated aldolase and glyceraldehyde-3-phosphate dehydrogenase in accordance with the chaperone model of HSPB1 and HSPB5. HSPB11 overexpression protected against etoposide-induced cell death which correlated with a decreased release of mitochondrial cytochrome c into the cytosol. Inhibiting HSP90 function completely abrogated the protective effect of HSPB11. This would suggest that at least in the case of HSPB11, interaction with other chaperone machines besides HSPA1A may contribute to functional specificity and cellular functioning.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heat Shock Protein Beta 11 (HSPb11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heat Shock Protein Beta 11 (HSPb11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heat Shock Protein Beta 11 (HSPb11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heat Shock Protein Beta 11 (HSPb11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heat Shock Protein Beta 11 (HSPb11) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heat Shock Protein Beta 11 (HSPb11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heat Shock Protein Beta 11 (HSPb11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heat Shock Protein Beta 11 (HSPb11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heat Shock Protein Beta 11 (HSPb11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heat Shock Protein Beta 11 (HSPb11) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Heat Shock Protein Beta 11 (HSPb11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Heat Shock Protein Beta 11 (HSPb11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Heat Shock Protein Beta 11 (HSPb11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Heat Shock Protein Beta 11 (HSPb11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Heat Shock Protein Beta 11 (HSPb11) ELISA Kit Customized Service Offer
  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Isolation and characterization of five new soluble placental tissue proteins (PP22, PP23, PP24, PP25, PP26)."Arch. Gynecol. Obstet. 248:111-115(1991) [PubMed] [Europe PMC] [Abstract]
  5. "Why proteins without an alpha-crystallin domain should not be included in the human small heat shock protein family HSPB."Cell Stress Chaperones 15:457-461(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "Improving NMR protein structure quality by Rosetta refinement: a molecular replacement study."Proteins 75:147-167(2009) [PubMed] [Europe PMC] [Abstract]