Coiled Coil Domain Containing Protein 135 (CCDC135)

CCDC135 is predicted to be a Cytosol/Nuclear protein with no transmembrane spans or segments. It is predicted to contain at least 56 specific phospohorylation sites which include: 20 Protein Kinase C Phosphorylation sites, 11 Casein Kinase II Phosphorylation sites, and 8 cAMP/cGMP Dependant Phosphorylation sites. The amino acid sequence is also predicted to contain 10 sumoylation sites at positions K236, K236, K45, K773, K499, K679, K249, K167, K540, K445, and K292.

The function of CCDC135 is not yet well understood but it is thought to be involved in teratospermia.The protein has 17 predicted alpha helices sites, a characteristic of coiled-coil proteins, and 1 predicted beta-pleated sheet.