Chromosome 1 Open Reading Frame 186 (C1orf186)
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Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes Lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. The C1orf186 gene product has been provisionally designated C1orf186 pending further characterization.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Chromosome 1 Open Reading Frame 186 (C1orf186) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Chromosome 1 Open Reading Frame 186 (C1orf186) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Chromosome 1 Open Reading Frame 186 (C1orf186) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Chromosome 1 Open Reading Frame 186 (C1orf186) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Chromosome 1 Open Reading Frame 186 (C1orf186) | ELISA Kit Customized Service Offer |
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]