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SprT Like N-Terminal Domain Containing Protein (SPRTN)

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DVC1; Spartan; C1orf124; DNA damage protein targeting VCP; Protein With SprT-Like Domain at The N Terminus

SprT Like N-Terminal Domain Containing Protein (SPRTN)
CCC R395
HGNC 25356
MGI 2685351
PubMed 23042605
RGD 1559496
UniProt Q9H040
Wiki C1orf124
C1orf124 is expressed at high level, 1.7 times the average gene in this release.C1orf124 contains 9 different gt-ag introns. Transcription produces 12 different mRNAs, 9 alternatively spliced variants and 3 unspliced forms. There are 4 probable alternative promotors, 4 non overlapping alternative last exons and 9 validated alternative polyadenylation sites. The mRNAs appear to differ by truncation of the 5' end, truncation of the 3' end, presence or absence of 3 cassette exons, overlapping exons with different boundaries, alternative splicing or retention of one intron.C1orf124 has been proposed to participate in a process (DNA repair). Proteins are expected to have molecular function (DNA binding) and to localize in various compartments (nuclear speck, cytoplasm, nucleus). A putative protein interactor has been described (RNF11).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SprT Like N-Terminal Domain Containing Protein (SPRTN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SprT Like N-Terminal Domain Containing Protein (SPRTN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SprT Like N-Terminal Domain Containing Protein (SPRTN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SprT Like N-Terminal Domain Containing Protein (SPRTN) CLIA Kit Customized Service Offer
n/a ELISA Kit for SprT Like N-Terminal Domain Containing Protein (SPRTN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SprT Like N-Terminal Domain Containing Protein (SPRTN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SprT Like N-Terminal Domain Containing Protein (SPRTN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SprT Like N-Terminal Domain Containing Protein (SPRTN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SprT Like N-Terminal Domain Containing Protein (SPRTN) CLIA Kit Customized Service Offer
n/a ELISA Kit for SprT Like N-Terminal Domain Containing Protein (SPRTN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant SprT Like N-Terminal Domain Containing Protein (SPRTN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to SprT Like N-Terminal Domain Containing Protein (SPRTN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to SprT Like N-Terminal Domain Containing Protein (SPRTN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for SprT Like N-Terminal Domain Containing Protein (SPRTN) CLIA Kit Customized Service Offer
n/a ELISA Kit for SprT Like N-Terminal Domain Containing Protein (SPRTN) ELISA Kit Customized Service Offer
  1. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Spartan/C1orf124 is important to prevent UV-induced mutagenesis."Cell Cycle 11:3395-3402(2012) [PubMed] [Europe PMC] [Abstract]
  8. "Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis."J. Biol. Chem. 287:34225-34233(2012) [PubMed] [Europe PMC] [Abstract]
  9. "Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response."Mol. Cell 46:625-635(2012) [PubMed] [Europe PMC] [Abstract]
  10. "DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage."Nat. Struct. Mol. Biol. 19:1093-1100(2012) [PubMed] [Europe PMC] [Abstract]
  11. "DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks."Nat. Struct. Mol. Biol. 19:1084-1092(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Characterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage tolerance."Nucleic Acids Res. 40:10795-10808(2012) [PubMed] [Europe PMC] [Abstract]
  13. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features." Nat. Genet. 46:1239-1244(2014) [PubMed] [Europe PMC] [Abstract]