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Ankyrin Repeat Domain Protein 13C (ANKRD13C)

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Ankyrin Repeat Domain Protein 13C (ANKRD13C)
CCC R404
HGNC 25374
MGI 2139746
PubMed 22298428
RGD 1595074
UniProt Q8N6S4
Wiki ANKRD13C
, a protein of unknown function, as an interacting partner for the DP receptor for prostaglandin D2. ANKRD13C is a protein associated with the cytosolic side of ER membranes. Co-expression of ANKRD13C with DP initially increased receptor protein levels, whereas siRNA-mediated knockdown of endogenous ANKRD13C decreased them. Pulse-chase experiments indicated that ANKRD13C can promote the biogenesis of DP by inhibiting the degradation of newly synthesized receptors. ANKRD13C also regulated the expression of other GPCRs tested, whereas it did not affect the expression of GFP, GRK2 and VSVG, showing specificity towards G protein-coupled receptors. ANKRD13C acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin Repeat Domain Protein 13C (ANKRD13C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin Repeat Domain Protein 13C (ANKRD13C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin Repeat Domain Protein 13C (ANKRD13C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin Repeat Domain Protein 13C (ANKRD13C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin Repeat Domain Protein 13C (ANKRD13C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin Repeat Domain Protein 13C (ANKRD13C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin Repeat Domain Protein 13C (ANKRD13C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin Repeat Domain Protein 13C (ANKRD13C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin Repeat Domain Protein 13C (ANKRD13C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin Repeat Domain Protein 13C (ANKRD13C) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin Repeat Domain Protein 13C (ANKRD13C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin Repeat Domain Protein 13C (ANKRD13C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin Repeat Domain Protein 13C (ANKRD13C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin Repeat Domain Protein 13C (ANKRD13C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin Repeat Domain Protein 13C (ANKRD13C) ELISA Kit Customized Service Offer
  1. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "ANKRD13C acts as a molecular Chaperone for G protein-coupled receptors."J. Biol. Chem. 285:40838-40851(2010) [PubMed] [Europe PMC] [Abstract]