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UAP56 Interacting Factor (UIF)

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FYTTD1; Forty-Two-Three Domain Containing 1

UAP56 Interacting Factor (UIF)
CCC R411
HGNC 25407
MGI 1917955
RGD 1306899
UniProt Q96QD9
The canonical adaptor REF/ALY/Yra1 is recruited to mRNA via UAP56 and subsequently delivers the mRNA to NXF1. Knockdown of UAP56 and NXF1 in higher eukaryotes efficiently blocks mRNA export, whereas knockdown of REF only causes a modest reduction, suggesting the existence of additional adaptors.UIF, which functions as an export adaptor, binding NXF1 and delivering mRNA to the nuclear pore. REF and UIF are simultaneously found on the same mRNA molecules, and both proteins are required for efficient export of mRNA. The histone chaperone FACT specifically binds UIF, but not REF, via the SSRP1 subunit, and this interaction is required for recruitment of UIF to mRNA. Together the results indicate that REF and UIF represent key human adaptors for the export of cellular mRNAs via the UAP56-NXF1 pathway.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UAP56 Interacting Factor (UIF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UAP56 Interacting Factor (UIF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UAP56 Interacting Factor (UIF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UAP56 Interacting Factor (UIF) CLIA Kit Customized Service Offer
n/a ELISA Kit for UAP56 Interacting Factor (UIF) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UAP56 Interacting Factor (UIF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UAP56 Interacting Factor (UIF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UAP56 Interacting Factor (UIF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UAP56 Interacting Factor (UIF) CLIA Kit Customized Service Offer
n/a ELISA Kit for UAP56 Interacting Factor (UIF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant UAP56 Interacting Factor (UIF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to UAP56 Interacting Factor (UIF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to UAP56 Interacting Factor (UIF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for UAP56 Interacting Factor (UIF) CLIA Kit Customized Service Offer
n/a ELISA Kit for UAP56 Interacting Factor (UIF) ELISA Kit Customized Service Offer
  1. Thesis (2001), Faculty of Biological Sciences / Goettingen, Germany
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  9. "UIF, a new mRNA export adaptor that works together with REF/ALY, requires FACT for recruitment to mRNA."Curr. Biol. 19:1918-1924(2009) [PubMed] [Europe PMC] [Abstract]
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