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Kelch Like Protein 22 (KLHL22)

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KELCHL

Kelch Like Protein 22 (KLHL22)
CCC R505
HGNC 25888
MGI 1337995
PubMed 23455478
RGD 1306288
UniProt Q53GT1
KLHL22 (kelch-like protein 22) is a 634 amino acid protein that is related to the Drosophila kelch protein, which is required to maintain Actin organization in ovarian ring canals. Mutations affecting Kelch function result in the failure of Kelch to associate with the ring canals and subsequent female sterility. Human KLHL22 protein contains six kelch repeats and one BTB (POZ) domain. The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (Poxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. There are two isoforms of KLHL22 that are produced as a result of alternative splicing events.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kelch Like Protein 22 (KLHL22) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kelch Like Protein 22 (KLHL22) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kelch Like Protein 22 (KLHL22) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kelch Like Protein 22 (KLHL22) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kelch Like Protein 22 (KLHL22) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kelch Like Protein 22 (KLHL22) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kelch Like Protein 22 (KLHL22) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kelch Like Protein 22 (KLHL22) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kelch Like Protein 22 (KLHL22) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kelch Like Protein 22 (KLHL22) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kelch Like Protein 22 (KLHL22) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kelch Like Protein 22 (KLHL22) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kelch Like Protein 22 (KLHL22) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kelch Like Protein 22 (KLHL22) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kelch Like Protein 22 (KLHL22) ELISA Kit Customized Service Offer
  1. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis."J. Cell Biol. 187:791-800(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  7. "Ubiquitylation-dependent localization of PLK1 in mitosis."Nat. Cell Biol. 15:430-439(2013) [PubMed] [Europe PMC] [Abstract]