RBPJ Interacting And Tubulin Associated Protein 1 (RITA1)
[Edit]RITA; C12orf52; RBP-J Interacting And Tubulin Associated
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The evolutionarily conserved Notch signal transduction pathway regulates fundamental cellular processes during embryonic development and in the adult. Notch intracellular domain (NICD) binds to the recombination signal sequence-binding protein J (RBP-J)/CBF-1 transcription factor to induce expression of Notch target genes. C12ORF52 as a novel RBP-J/CBF-1-interacting protein. RITA is a highly conserved 36 kDa protein that, most interestingly, binds to tubulin in the cytoplasm and shuttles rapidly between cytoplasm and nucleus. This shuttling RITA exports RBP-J/CBF-1 from the nucleus. RITA can reverse a Notch-induced loss of primary neurogenesis in Xenopus laevis. RITA is able to downregulate Notch-mediated transcription. RITA acts as a negative modulator of the Notch signalling pathway, controlling the level of nuclear RBP-J/CBF-1, where its amounts are limiting.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant RBPJ Interacting And Tubulin Associated Protein 1 (RITA1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to RBPJ Interacting And Tubulin Associated Protein 1 (RITA1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to RBPJ Interacting And Tubulin Associated Protein 1 (RITA1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for RBPJ Interacting And Tubulin Associated Protein 1 (RITA1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for RBPJ Interacting And Tubulin Associated Protein 1 (RITA1) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant RBPJ Interacting And Tubulin Associated Protein 1 (RITA1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to RBPJ Interacting And Tubulin Associated Protein 1 (RITA1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to RBPJ Interacting And Tubulin Associated Protein 1 (RITA1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for RBPJ Interacting And Tubulin Associated Protein 1 (RITA1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for RBPJ Interacting And Tubulin Associated Protein 1 (RITA1) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant RBPJ Interacting And Tubulin Associated Protein 1 (RITA1) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to RBPJ Interacting And Tubulin Associated Protein 1 (RITA1) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to RBPJ Interacting And Tubulin Associated Protein 1 (RITA1) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | n/a | CLIA Kit for RBPJ Interacting And Tubulin Associated Protein 1 (RITA1) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for RBPJ Interacting And Tubulin Associated Protein 1 (RITA1) | ELISA Kit Customized Service Offer |
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- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J."EMBO J. 30:43-56(2011) [PubMed] [Europe PMC] [Abstract]