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PCNA Interacting Partner (PARI)

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C12orf48; PARPBP; PARP1-binding protein

PCNA Interacting Partner (PARI)
CCC R548
HGNC 26074
MGI 1922567
PubMed 23436799
UniProt Q9NWS1
C12orf48, Belongs to the UPF0419 (AROM) family. May be involved in RNA metabolism. Binds single-strand DNA and poly(A) homopolymers
Objective methods for diagnosing a predisposition to developing pancreatic cancer and prostate cancer, particularly pancreatic ductal adenocarcinoma (PDAC) and castration-resistant prostate cancer, are described herein. In one embodiment, the diagnostic method involves the step of determining an expression level of C12ORF48 using siRNAs targeting the C12ORF48 gene. C12ORF48 associated disease, such as a cancer, e.g. pancreatic cancer and prostate cancer, as well as methods of inhibiting the cell growth and treating or alleviating one or more disease symptoms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PCNA Interacting Partner (PARI) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PCNA Interacting Partner (PARI) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PCNA Interacting Partner (PARI) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PCNA Interacting Partner (PARI) CLIA Kit Customized Service Offer
n/a ELISA Kit for PCNA Interacting Partner (PARI) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant PCNA Interacting Partner (PARI) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to PCNA Interacting Partner (PARI) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to PCNA Interacting Partner (PARI) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for PCNA Interacting Partner (PARI) CLIA Kit Customized Service Offer
n/a ELISA Kit for PCNA Interacting Partner (PARI) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "C12orf48, termed PARP-1 binding protein, enhances poly(ADP-ribose) polymerase-1 (PARP-1) activity and protects pancreatic cancer cells from DNA damage."Genes Chromosomes Cancer 50:13-24(2011) [PubMed] [Europe PMC] [Abstract]
  5. "Inhibition of homologous recombination by the PCNA-interacting protein PARI."Mol. Cell 45:75-86(2012) [PubMed] [Europe PMC] [Abstract]