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DENN/MADD Domain Containing Protein 2D (DENND2D)

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DENN/MADD Domain Containing Protein 2D (DENND2D)
CCC R575
HGNC 26192
MGI 2181193
PubMed 23182661
RGD 1305120
UniProt Q9H6A0
Gene identification by nonsense-mediated mRNA decay inhibition (GINI) has proven to be a strategy for genome-wide discovery of genes containing inactivating mutations in colon and prostate cancers. Stringent analysis of the array data was used to select 35 candidate genes for sequencing. Of these, 4 (11%) were found to carry PTCs, including ARHGEF17, DENND2D, FGFR3, and RB1.
ARHGEF17 showed a G1865A mutation leading to W622X in a cell line derived from a mucosal melanoma; in RB1 a C1411T base change resulting in Q471X was discovered in a cell line derived from an acral melanoma; and the FGFR3 and DENND2D genes had intronic insertions leading to PTCs in cell lines derived from superficially spreading melanomas.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DENN/MADD Domain Containing Protein 2D (DENND2D) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DENN/MADD Domain Containing Protein 2D (DENND2D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DENN/MADD Domain Containing Protein 2D (DENND2D) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DENN/MADD Domain Containing Protein 2D (DENND2D) CLIA Kit Customized Service Offer
n/a ELISA Kit for DENN/MADD Domain Containing Protein 2D (DENND2D) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DENN/MADD Domain Containing Protein 2D (DENND2D) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DENN/MADD Domain Containing Protein 2D (DENND2D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DENN/MADD Domain Containing Protein 2D (DENND2D) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DENN/MADD Domain Containing Protein 2D (DENND2D) CLIA Kit Customized Service Offer
n/a ELISA Kit for DENN/MADD Domain Containing Protein 2D (DENND2D) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant DENN/MADD Domain Containing Protein 2D (DENND2D) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to DENN/MADD Domain Containing Protein 2D (DENND2D) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to DENN/MADD Domain Containing Protein 2D (DENND2D) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for DENN/MADD Domain Containing Protein 2D (DENND2D) CLIA Kit Customized Service Offer
n/a ELISA Kit for DENN/MADD Domain Containing Protein 2D (DENND2D) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors."J. Cell Biol. 191:367-381(2010) [PubMed] [Europe PMC] [Abstract]
  5. "Suppression of non-small cell lung cancer proliferation and tumorigenicity by DENND2D."Lung Cancer 79:104-110(2013) [PubMed] [Europe PMC] [Abstract]
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]