Zinc Finger, CCHC Domain Containing Protein 7 (ZCCHC7)

ZCCHC7 contains 4 CCHC-type zinc fingers and it has two isoforms. Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all.

This entry represents the CysCysHisCys (CCHC) type zinc finger domains, and have the sequence: C-X2-C-X4-H-X4-C. where X can be any amino acid, and number indicates the number of residues. These 18 residues CCHC zinc finger domains are mainly found in the nucleocapsid protein of retroviruses. It is required for viral genome packaging and for early infection process. It is also found in eukaryotic proteins involved in RNA binding or single-stranded DNA binding.