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ATP/GTP Binding Protein Like Protein 2 (AGBL2)

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CCP2; Cytosolic carboxypeptidase

ATP/GTP Binding Protein Like Protein 2 (AGBL2)
CCC R595
HGNC 26296
MGI 2443254
RGD 1306827
UniProt Q5U5Z8
AGBL2, Belongs to the peptidase M14 family. may play a role in the processing of tubulin. RARRES1 interacts with and regulates the activity of a novel cytosolic carboxypeptidase (AGBL2) that detyrosinates the C-terminal EEY-regions of alpha-tubulin and EB1, a protein involved in microtubule stability. RARRES1 is a Golgi-associated transmembrane protein that is transported to the cleavage furrow and midbody in dividing cells.
Depletion of RARRES1 increased the incidence of multinucleated cells and impedes cell motility. This data points to a role for RARRES1, AGBL2, EB1 and the microtubule tyrosination cycle in cytokinesis, tumorigenesis and stem cell lineage specification and identify a novel area for intervention.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP/GTP Binding Protein Like Protein 2 (AGBL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP/GTP Binding Protein Like Protein 2 (AGBL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP/GTP Binding Protein Like Protein 2 (AGBL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP/GTP Binding Protein Like Protein 2 (AGBL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP/GTP Binding Protein Like Protein 2 (AGBL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP/GTP Binding Protein Like Protein 2 (AGBL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP/GTP Binding Protein Like Protein 2 (AGBL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP/GTP Binding Protein Like Protein 2 (AGBL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP/GTP Binding Protein Like Protein 2 (AGBL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP/GTP Binding Protein Like Protein 2 (AGBL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant ATP/GTP Binding Protein Like Protein 2 (AGBL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to ATP/GTP Binding Protein Like Protein 2 (AGBL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to ATP/GTP Binding Protein Like Protein 2 (AGBL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for ATP/GTP Binding Protein Like Protein 2 (AGBL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for ATP/GTP Binding Protein Like Protein 2 (AGBL2) ELISA Kit Customized Service Offer
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the alpha-tubulin tyrosination cycle."Cancer Res. 71:1219-1228(2011) [PubMed] [Europe PMC] [Abstract]
  5. "Functional segregation and emerging role of cilia-related cytosolic carboxypeptidases (CCPs)."FASEB J. 27:424-431(2013) [PubMed] [Europe PMC] [Abstract]