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Peroxidasin Like Protein (PXDNL)

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VPO2; PRM1; Cardiac peroxidase; Vascular peroxidase 2; polysomal ribonuclease 1

Peroxidasin Like Protein (PXDNL)
CCC R605
HGNC 26359
PubMed 22543864
UniProt A1KZ92
PXDNL belongs to the peroxidase family. PXDNL is moderately expressed, only 28.6% of the average gene in this release, PXDNL contains 23 different gt-ag introns.
XPO subfamily. Dysfunction of mitochondria in nerve cells contributes to the neurodegeneration of PD. When cells are infected by the CMV virus, they become resistant to certain mitochondrial toxins that may be important in causing PD. CMV-infected cells produce very high levels of a protein called PXDNL about which very little is known. PXDNL is selectively found in substantia nigra neurons, increasing its levels will detoxify the free radicals produced by malfunctioning mitochondria and thereby protect these neurons. PXDNL may protect against these toxic processes and, if so, it may open the way for a new approach to slowing or halting the progression of the disease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peroxidasin Like Protein (PXDNL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peroxidasin Like Protein (PXDNL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peroxidasin Like Protein (PXDNL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peroxidasin Like Protein (PXDNL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peroxidasin Like Protein (PXDNL) ELISA Kit Customized Service Offer
  1. "Identification and characterization of VPO1, a new animal heme-containing peroxidase."Free Radic. Biol. Med. 45:1682-1694(2008) [PubMed] [Europe PMC] [Abstract]
  2. "DNA sequence and analysis of human chromosome 8." Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "An endonuclease activity similar to Xenopus PMR1 catalyzes the degradation of normal and nonsense-containing human beta-globin mRNA in erythroid cells."RNA 9:1157-1167(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein."RNA 18:1186-1196(2012) [PubMed] [Europe PMC] [Abstract]